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Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry.

Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain. Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain. fjfuentesjimenez@gmail.com. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. fjfuentesjimenez@gmail.com. Internal Medicine Department, Juan Ramón Jiménez Hospital, Huelva, Spain. Internal Medicine Department, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain. Internal Medicine Department, Royo Villanova Hospital, Zaragoza, Spain. Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Toledo, Spain. Internal Medicine Department, Ramón y Cajal University Hospital, Madrid, Spain. Internal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain. Internal Medicine Department, Infanta Cristina University Hospital, Parla, Madrid, Spain. Internal Medicine Department, Cabueñes Hospital, Gijón, Asturias, Spain. Internal Medicine Department, Henares Hospital, Coslada, Madrid, Spain. Internal Medicine Department, San Juan de Alicante University Hospital, San Juan de Alicante, Alicante, Spain. Internal Medicine Department, La Fe University Hospital, Valencia, Spain. Internal Medicine Department, San Pedro Hospital, Logroño, La Rioja, Spain. Internal Medicine Department, Mataró Hospital, Mataró, Barcelona, Spain. Internal Medicine Department, Alto Guadalquivir Hospital, Andújar, Jaén, Spain. Internal Medicine Department, Marina Baixa Hospital, Villajoyosa, Alicante, Spain. Internal Medicine Department, Badajoz University Hospital Complex, Badajoz, Spain. Internal Medicine Department, Francesc de Borja Hospital, Gandía, Valencia, Spain. Department of Clinical Medicine, Miguel Hernandez University of Elche, Alicante, Spain.

Drugs. 2021;(6):685-695
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Abstract

BACKGROUND The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with COVID-19 have reduced in-hospital mortality if statin therapy is maintained during hospitalization. METHODS This work is a cross-sectional, observational, retrospective multicenter study that analyzed 2921 patients who required hospital admission at 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics and COVID-19 disease outcomes between patients receiving chronic statin therapy who maintained this therapy during hospitalization versus those who did not. Propensity score matching was used to match each statin user whose therapy was maintained during hospitalization to a statin user whose therapy was withdrawn during hospitalization. RESULTS After propensity score matching, continuation of statin therapy was associated with lower all-cause mortality (OR 0.67, 0.54-0.83, p < 0.001); lower incidence of acute kidney injury (AKI) (OR 0.76,0.6-0.97, p = 0.025), acute respiratory distress syndrome (ARDS) (OR 0.78, 0.69- 0.89, p < 0.001), and sepsis (4.82% vs 9.85%, p = 0.008); and less need for invasive mechanical ventilation (IMV) (5.35% vs 8.57, p < 0.001) compared to patients whose statin therapy was withdrawn during hospitalization. CONCLUSIONS Patients previously treated with statins who are hospitalized for COVID-19 and maintain statin therapy during hospitalization have a lower mortality rate than those in whom therapy is withdrawn. In addition, statin therapy was associated with a decreased probability that patients with COVID-19 will develop AKI, ARDS, or sepsis and decreases the need for IMV.

Methodological quality

Publication Type : Multicenter Study ; Observational Study

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